Phytochemistry and Biological Activities of Endophytic Fungi from the Meliaceae Family.

Meliaceae plants are found worldwide in tropical or subtropical climates. They are important ethnobotanically as sources of traditional medicine, with 575 species and 51 genera. Previous research found that microorganisms are plant pioneers to produce secondary metabolites with diverse compound structures and bioactivities. Several plants of the Meliaceae family contain secondary metabolites isolated from endophytic fungi. Furthermore, related articles from 2002 to 2022 were collected from SciFinder, Google Scholar, and PubMed. About 276 compounds were isolated from endophytic fungi such as terpenoids, polyketides, lactones, pyrones, quinone, anthraquinones, xanthones, coumarines, isocoumarines, resorcylic acid lactones, cytochalasins, aromatics, ester, quinols, alkaloids, nitro compound, fatty acids, and sugars with bioactivities such as antioxidant, antibacterial, antifungal, anti-influenza, neuroprotective activities, anti-HIV, cytotoxic, allelopathic, anti-inflammatory, antifeedant effects, and BSLT toxicity. Meanwhile, secondary metabolites isolated from endophytic fungi were reported as one of the sources of active compounds for medicinal chemistry. This comprehensive review summarizes the ethnobotanical uses and secondary metabolites derived from Meliaceae endophytic fungi.

Phytochemistry and Biological Activities of Guarea Genus (Meliaceae).

Guarea is one of the largest genera of the American Meliaceae family, consisting of over 69 species which are widely distributed in Mexico, Argentina, and Africa and are used in traditional medicine for several diseases. Previous studies reported that the Guarea species produce secondary metabolites such as sesquiterpenoid, diterpenoid, triterpenoid, limonoid, steroid, and aromatic compounds. The preliminary chemical investigation commenced by isolating the limonoid compound, dihydrogedunin, in 1962; then, 240 compounds were obtained from the isolation and hydrodistillation process. Meanwhile, sesquiterpenoid is a significant compound with 52% of Guarea species. The extract and compounds were evaluated for their anti-inflammation, antimalarial, antiparasitic, antiprotozoal, antiviral, antimicrobial, insecticidal, antioxidant, phosphorylation inhibitor, and cytotoxic biological activities. The Guarea genus has also been reported as one of the sources of active compounds for medicinal chemistry. This review summarizes some descriptions regarding the types of Guarea species, especially ethnobotany and ethnopharmacology, such as the compounds isolated from the part of this genus, various isolation methods, and their bioactivities. The information can be used in further investigations to obtain more bioactive compounds and their reaction mechanisms.

Phytochemistry and biological activity of Lansium domesticum Corr. species: a review.

OBJECTIVES: This study aims to review and describe the ethnobotanical, phytochemical and biological activity of various extracts and compounds isolated from Lansium domesticum Corr. from 1967 to 2022 and to study the opportunities that can be developed in the future in the pharmaceutical and pharmacology fields. The related articles, followed by the classification of L. domesticum Corr. according to ethnobotanical, biological and phytochemical properties, were collected from SciFinder, Google Scholar and PubMed. KEY FINDINGS: More than 80 compounds have been isolated and identified from L. domesticum Corr., including terpenoids and their glycosides. Furthermore, the pharmacological activity of the extracts and pure compounds of L. domesticum Corr. tested in vitro and in vivo were mainly confirmed to include antifeedant, antimalarial, antimicrobial, antibacterial, and radical scavenging activity, antimutagenic, and anticancer. SUMMARY: In conclusion, based on this review, all data on the phytochemical and biological activity of L. domesticum Corr. can be used to support scientists in further research aim to determine the reaction mechanism of the extracts or compounds and need to be further validated using in vivo models together with toxicological analysis to establish their maximum tolerated dose.